Behavioral, computational, and neuroimaging studies of acquired apraxia of speech

A critical examination of speech motor control depends on an in-depth understanding of network connectivity associated with Brodmann areas 44 and 45 and surrounding cortices. Damage to these areas has been associated with two conditions-the speech motor programming disorder apraxia of speech (AOS) and the linguistic/grammatical disorder of Broca's aphasia. Here we focus on AOS, which is most commonly associated with damage to posterior Broca's area (BA) and adjacent cortex. We provide an overview of our own studies into the nature of AOS, including behavioral and neuroimaging methods, to explore components of the speech motor network that are associated with normal and disordered speech motor programming in AOS. Behavioral, neuroimaging, and computational modeling studies are indicating that AOS is associated with impairment in learning feedforward models and/or implementing feedback mechanisms and with the functional contribution of BA6. While functional connectivity methods are not yet routinely applied to the study of AOS, we highlight the need for focusing on the functional impact of localized lesions throughout the speech network, as well as larger scale comparative studies to distinguish the unique behavioral and neurological signature of AOS. By coupling these methods with neural network models, we have a powerful set of tools to improve our understanding of the neural mechanisms that underlie AOS, and speech production generally

SOAR (Support Office for Aerogeophysical Research) Annual Report 1994/1995

The Support Office for Aerogeophysical Research (SOAR) was a facility of the National Science Foundation's Office of Polar Programs whose mission is to make airborne geophysical observations available to the broad research community of geology, glaciology and other sciences. The central office of the SOAR facility is located in Austin, Texas within the University of Texas Institute for Geophysics. Other institutions with significant responsibilities are the Lamont­ Doherty Earth Observatory of Columbia University and the Geophysics Branch of the U.S . Geological Survey. This report summarizes the goals and accomplishments of the SOAR facility during 1994/1995 and plans for the next year.National Science Foundation's Office of Polar ProgramsInstitute for Geophysic

The Effect of Focal Cerebral Lesions on Intramodal and Cross-modal Orienting of Attention

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Isolated Thalamic Lesion and Aphasia: A Case Study

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Functional role of delta and theta band oscillations for auditory feedback processing during vocal pitch motor control

The answer to the question of how the brain incorporates sensory feedback and links it with motor function to achieve goal-directed movement during vocalization remains unclear. We investigated the mechanisms of voice pitch motor control by examining the spectro-temporal dynamics of EEG signals when non-musicians (NM), relative pitch (RP) and absolute pitch (AP) musicians maintained vocalizations of a vowel sound and received randomized ±100 cents pitch-shift stimuli in their auditory feedback. We identified a phase-synchronized (evoked) fronto-central activation within the theta band (5-8 Hz) that temporally overlapped with compensatory vocal responses to pitch-shifted auditory feedback and was significantly stronger in RP and AP musicians compared with non-musicians. A second component involved a non-phase-synchronized (induced) frontal activation within the delta band (1-4 Hz) that emerged at approximately 1 second after the stimulus onset. The delta activation was significantly stronger in the NM compared with RP and AP groups and correlated with the pitch rebound error (PRE), indicating the degree to which subjects failed to re-adjust their voice pitch to baseline after the stimulus offset. We propose that the evoked theta is a neurophysiological marker of enhanced pitch processing in musicians and reflects mechanisms by which humans incorporate auditory feedback to control their voice pitch. We also suggest that the delta activation reflects adaptive neural processes by which vocal production errors are monitored and used to update the state of sensory-motor networks for driving subsequent vocal behaviors. This notion is corroborated by our findings showing that larger PREs were associated with greater delta band activity in the NM compared with RP and AP groups. These findings provide new insights into the neural mechanisms of auditory feedback processing for vocal pitch motor control

Airborne gravity and precise positioning for geologic applications

Airborne gravimetry has become an important geophysical tool primarily because of advancements in methodology and instrumentation made in the past decade. Airborne gravity is especially useful when measured in conjunction with other geophysical data, such as magnetics, radar, and laser altimetry. The aerogeophysical survey over the West Antarctic ice sheet described in this paper is one such interdisciplinary study. This paper outlines in detail the instrumentation, survey and data processing methodology employed to perform airborne gravimetry from the multiinstrumented Twin Otter aircraft. Precise positioning from carrier-phase Global Positioning System (GPS) observations are combined with measurements of acceleration made by the gravity meter in the aircraft to obtain the free-air gravity anomaly measurement at aircraft altitude. GPS data are processed using the Kinematic and Rapid Static (KARS) software program, and aircraft vertical acceleration and corrections for gravity data reduction are calculated from the GPS position solution. Accuracies for the free-air anomaly are determined from crossover analysis after significant editing (2.98 mGal rms) and from a repeat track (1.39 mGal rms). The aerogeophysical survey covered a 300,000 km2 region in West Antarctica over the course of five field seasons. The gravity data from the West Antarctic survey reveal the major geologic structures of the West Antarctic rift system, including the Whitmore Mountains, the Byrd Subglacial Basin, the Sinuous Ridge, the Ross Embayment, and Siple Dome. These measurements, in conjunction with magnetics and ice-penetrating radar, provide the information required to reveal the tectonic fabric and history of this important region

The Use of Signal Detection Theory to Evaluate Aphasia Diagnostic Accuracy and Clinician Bias

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Generalized motor programme and parameterization accuracy in apraxia of speech and conduction aphasia

The present study examined three aspects of motor programming (generalized motor programme (GMP) accuracy, temporal parameterization accuracy, and amplitude parameterization accuracy) in subjects with apraxia of speech (AOS) or conduction aphasia (CA) and normal speaking participants. Subjects were presented with a movement pattern on a monitor that they were required to produce with the jaw, after the target pattern had been removed from view. Analyses examined differences in relative (parameterization) and absolute (GMP) timing and amplitude between the target and actual movement. Examination of individual subject performance revealed inter- subject variability within the AOS group, with two of the four subjects demonstrating unimpaired GMP accuracy but poor parameterization accuracy, while the other two subjects exhibited the opposite pattern, impaired GMP accuracy but normal parameterization. No clear pattern of deficit was noted for the subjects with CA. Results are discussed with respect to motor control theories of AOS and CA

The Use of Signal Detection Theory to Evaluate Aphasia Diagnostic Accuracy and Clinician Bias (Erratum)

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Reference hydrologic networks II: using reference hydrologic networks to assess climate-driven changes in streamflow

Reference hydrologic networks (RHNs) can play an important role in monitoring for changes in the hydrological regime related to climate variation and change. Currently, the literature concerning hydrological response to climate variations is complex and confounded by the combinations of many methods of analysis, wide variations in hydrology, and the inclusion of data series that include changes in land use, storage regulation and water use in addition to those of climate. Three case studies that illustrate a variety of approaches to the analysis of data from RHNs are presented and used, together with a summary of studies from the literature, to develop approaches for the investigation of changes in the hydrological regime at a continental or global scale, particularly for international comparison. We present recommendations for an analysis framework and the next steps to advance such an initiative. There is a particular focus on the desirability of establishing standardized procedures and methodologies for both the creation of new national RHNs and the systematic analysis of data derived from a collection of RHNs